Acetylcholine Gate

This page discusses the nicotinic acetylcholine receptor.  For information on the muscarinic receptor, please see:  Acetylcholine Metabotropic Receptor

Acetylcholine (Wiki) 
http://en.wikipedia.org/wiki/Acetylcholine 
"The chemical compound acetylcholine (often abbreviated ACh) is a neurotransmitter in both the peripheral nervous system (PNS) and central nervous system (CNS) in many organisms including humans. Acetylcholine is one of many neurotransmitters in the autonomic nervous system (ANS) and the only neurotransmitter used in the motor division of the somatic nervous system. (Sensory neurons use glutamate and various peptides at their synapses.) Acetylcholine is also the principal neurotransmitter in all autonomic ganglia."

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There are two main classes of acetylcholine receptor (AChR), nicotinic acetylcholine receptors (nAChR) and muscarinic acetylcholine receptors (mAChR). They are named for the ligands used to activate the receptors.
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When acetylcholine binds to acetylcholine receptors on skeletal muscle fibers, it opens ligand-gated sodium channels in the cell membrane. Sodium ions then enter the muscle cell, initiating a sequence of steps that finally produce muscle contraction.



Nicotinic acetylcholine receptor (Wiki)   
http://en.wikipedia.org/wiki/Nicotinic_acetylcholine_receptors 
"Nicotinic acetylcholine receptors, or nAChRs, are cholinergic receptors that form ligand-gated ion channels in the plasma membranes of certain neurons and on the postsynaptic side of the neuromuscular junction . Being ionotropic receptors, nAChRs are directly linked to an ion channel and do not make use of a second messenger as metabotropic receptors do.[1]

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Nicotinic receptors ... possess similarities
with GABAA receptors, glycine receptors, and the type 3 serotonin receptors (which are all ionotropic receptors), or the signature Cys-loop proteins.[5]




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