Glutamate Metabotropic Receptor


For information on the glutamate ionotropic receptor, please see: 
Glutamate Gate

Glutamate Receptor (Wiki) 
http://en.wikipedia.org/wiki/Glutamate_receptor 

"
Glutamate receptors can be divided into two groups according to the mechanism by which their activation gives rise to a postsynaptic current.[8]

Ionotropic glutamate receptors (iGluRs) form the ion channel pore that activates when glutamate binds to the receptor.

Metabotropic glutamate receptors (mGluRs) indirectly activate ion-channels on the plasma membrane through a signaling cascade that involves G proteins. Ionotropic receptors tend to be quicker in relaying information but metabotropic are associated with a more prolonged stimulus." 

"Glutamate receptors are synaptic receptors located primarily on the membranes of neuronal cells. Glutamate is one of the 20 amino acids used to assemble proteins and as a result is abundant in many areas of the body, but it also functions as a neurotransmitter and is particularly abundant in the nervous system. Glutamate receptors are responsible for the glutamate-mediated post-synaptic excitation of neural cells, and are important for neural communication, memory formation, learning, and regulation."
 

Metabotropic glutamate receptor (Wiki) 
http://en.wikipedia.org/wiki/Metabotropic_glutamate_receptor 
"The metabotropic glutamate receptors, or mGluRs, are a type of glutamate receptor which are active through an indirect metabotropic process. They are members of the group C family of G-protein-coupled receptors, or GPCRs.[2] Like all glutamate receptors, mGluRs bind with glutamate, an amino acid that functions as an excitatory neurotransmitter.

"
Eight different types of mGluRs, labeled mGluR1 to mGluR8 (GRM1 to GRM8), are divided into groups I, II, and III.[2][4][5][8] Receptor types are grouped based on receptor structure and physiological activity.[3] The mGluRs are further divided into subtypes, such as mGluR7a and mGluR7b.


The...Metabotropic Glutamate Receptor is Related to Bacterial... (PubMed) 
http://www.ncbi.nlm.nih.gov/pubmed/8338667?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_SingleItemSupl.Pubmed_Discovery_RA&linkpos=1&log$=relatedarticles&logdbfrom=pubmed 
Abstract only. 
"
Receptors for the major excitatory neurotransmitter glutamate include metabotropic (G protein-coupled) and ionotropic (glutamate-gated ion channel) types...the metabotropic receptor extracellular domain is similar to bacterial periplasmic amino acid binding proteins.




Tuning and playing a motor rhythm: how metabotropic glutamate receptors orchestrate generation of motor patterns in the mammalian central nervous system (Goog)
http://jp.physoc.org/content/572/2/323.full 
Full length HTML available online for free. 
    See:
Amphioxus Locomotion .      


1997   
335<518        Free Article 
Metabotropic glutamate receptors regulate N-methyl-D-aspartate-mediated synaptic transmission in nucleus accumbens.
   
    Abstract: 
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