Human Serotonin

Cross references:
Serotonin Gate (5-HT3R)                Serotonin Metabotropic Receptor   
Serotonin Receptor Evolution       Amphioxus Serotonin System 
Reverse Engineering Amphioxus Serotonin    Lamprey Serotonin System    
Comparing Amphioxus and Lamprey Serotonin
Rodent 5-HT1R     Rodent 5-HT3R       
Vasopressin, Serotonin & Aggression 
Testosterone Serotonin Interaction     
Rodent Testosterone 5-HT Interaction    
Serotonin References



FINAL SUMMARY
OF THREE REFERENCES
1986 - 1999


    "Decreases in serotonin transmission seem to be associated with the increased performance of behaviors that are usually suppressed


INITIAL SUMMARIES
OF THE REFERENCES


Following are initial summaries of the references.  The summaries are identified by the first words of the references title and the year of publication.   
The references themselves follow this list of their initial summaries.
 




Reconciling the role of central serotonin ...1986 
    "Decreases in serotonin transmission seem to be associated with the increased performance of behaviors that are usually suppressed"   


An association between low levels of 5-HIAA and HVA ... 1993    
    "There were significant direct correlations between age at death and both CSF 5-HIAA and HVA in the deceased patients."   


Behavioral disinhibition induced by tryptophan depletion ... 1999    
    "
Low Serotonin levels may be implicated in the high disinhibition or Impulsive observed in some individuals with a genetic vulnerability to alcohol abuse or dependence."    




THE REFERENCES


Reconciling the role of central serotonin neurones in human and animal behavior (Goog)  - 1986       
http://journals.cambridge.org/action/displayAbstract?fromPage=online&aid=6759740   
Only abstract available online.  I got the 46 page PDF through the library.
Note: Google found 5 CotA hits for this, 
from the abstract    
    "
Decreases in serotonin transmission seem to be associated with the increased performance of behaviors that are usually suppressed, though not necessarily because of the alleviation of anxiety, which might contribute to the suppression.
"
my impression of the PDF from memory
    This is a very long review of more-or-less everything that was known about serotonin 25 years ago.   It hypothesizes that in the strong correlation between elevated circulating cortisol and elevated
Serotonin activity, it is the elevated Serotonin that is the cause and the elevated cortisol that is the effect.  However, it does not offer an explanation of how elevated Serotonin causes elevated cortisol.   
    An alternative hypothesis is that the elevated cortisol is the cause and the elevated serotonin is the effect.  Cortisol suppresses the sensitivity of lutenizing hormone receptors on the testes, thereby reducing the production of testosterone.  Since testosterone inhibits serotonergic receptors, the elevated circulating cortisol causes elevated serotonin activity by reducing the inhibitory effect of testosterone.   

   
    Full disclosure:  their position is supported by a reference that claims that "Treatment with 8-hydroxy-2(di-n- propylamino)tetralin, a specific 5-HT1A receptor agonist, elevates plasma cortisol concentrations in catheterized rainbow trout in a dosedependent manner (34)."   
    NOTE:  The 'full disclosure', above, doesn't seem to be from the paper.  The paper doesn't use reference numbers like '(34). 


An association between low levels of 5-HIAA and HVA in cerebrospinal fluid and early mortality in a diagnostically mixed psychiatric sample. - 1993    
Only abstract available online. 
    "
Seven of these patients died at age < or = 40, largely of suicide, homicide, or accidental causes. These seven patients had significantly lower CSF 5-HIAA and HVA than living control patients. There were significant direct correlations between age at death and both CSF 5-HIAA and HVA in the deceased patients. The results offer support for CSF monoamine metabolites relating to early death in a diagnostically diverse sample of psychiatric patients.



Behavioral disinhibition induced by tryptophan depletion in nonalcoholic young men with multigenerational family histories of paternal alcoholism.  
Full length HTML and PDF available online for free.    - 1999   
from the abstract 
    "
Tryptophan depletion had no effect on aggressive response. In contrast, tryptophan-depleted individuals with a family history of alcoholism made more commission errors ... Low
Serotonin levels may be implicated in the high disinhibition or Impulsive observed in some individuals with a genetic vulnerability to alcohol abuse or dependence."





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