Rodent Glucocorticoid-Serotonin Interaction

Cross references:      Rodent 5-HT1R    Rodent 5-HT3R     
Rodent Serotonin & Aggression      Rodent Testosterone    
Serotonin References    


NOTE:  I searched Google for "
glucocorticoids 5-HIAA/5-HT".  The reference, below, was the only one in the first four pages that seemed useful. 


Glucocorticoid receptor impairment alters CNS responses to a psychological stressor: an in vivo microdialysis study in transgenic mice (Goog) 
Only abstract available online. 
I was able to make a webpage folder download through the library.   
    "
Here we investigated putative disturbances on the level of brain neurotransmission in GR-impaired (GR-i) (transgenic) mice ...
"   
    "
 During the rat exposure period, control mice remained mostly sitting and/or lying with their eyes fixed on the rat. Moreover, they showed a profound rise in free corticosterone levels. In contrast, GR-i mice displayed significantly more activities along the separation wall and a trend toward more grooming behaviour, but no increase of free corticosterone. In both mouse lines, exposure to a rat increased hippocampal extracellular levels of 5-HT and 5-HIAA. The rise in 5-HT was, however, more pronounced in the GR-i mice."   
My comments
1.  As far as I can tell from the Abstract, the lack of a glucocorticoid stress response in the
GR-impaired transgenic mice slightly decreased the 5-HIAA/5-HT ratio.  The effect doesn't seem to have been very pronounced and was in the direction opposite that expected in response to stress. 
2.  Since both 5-HT and 5-HIAA rose in the transgenic mouse lacking GR in response to stress, there must be some other mechanism influencing the 5-HT and 5-HIAA levels.  Since the increases were in the hippocampus, perhaps they were due to cognition or memory.     


NOTE:  I searched Google for "
11βHSD1 5-HIAA/5-HT", and I didn't find anything in the first four pages that seemed useful. 


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