Cross references: Rodent 5-HT1R Rodent 5-HT3R Rodent Serotonin & Aggression Rodent Testosterone Serotonin References NOTE: I searched Google for "glucocorticoids 5-HIAA/5-HT". The reference, below, was the only one in the first four pages that seemed useful. Glucocorticoid receptor impairment alters CNS responses to a psychological stressor: an in vivo microdialysis study in transgenic mice (Goog) Only abstract available online. I was able to make a webpage folder download through the library. "Here we investigated putative disturbances on the level of brain neurotransmission in GR-impaired (GR-i) (transgenic) mice ..." " During the rat exposure period, control mice remained mostly sitting and/or lying with their eyes fixed on the rat. Moreover, they showed a profound rise in free corticosterone levels. In contrast, GR-i mice displayed significantly more activities along the separation wall and a trend toward more grooming behaviour, but no increase of free corticosterone. In both mouse lines, exposure to a rat increased hippocampal extracellular levels of 5-HT and 5-HIAA. The rise in 5-HT was, however, more pronounced in the GR-i mice." My comments: 1. As far as I can tell from the Abstract, the lack of a glucocorticoid stress response in the GR-impaired transgenic mice slightly decreased the 5-HIAA/5-HT ratio. The effect doesn't seem to have been very pronounced and was in the direction opposite that expected in response to stress. 2. Since both 5-HT and 5-HIAA rose in the transgenic mouse lacking GR in response to stress, there must be some other mechanism influencing the 5-HT and 5-HIAA levels. Since the increases were in the hippocampus, perhaps they were due to cognition or memory. NOTE: I searched Google for "11βHSD1 5-HIAA/5-HT", and I didn't find anything in the first four pages that seemed useful. |