Rodent Serotonin & Aggression

Cross references:   Serotonin References    

Intraspecific aggressiveness after lesions of midbrain raphe nuclei in
rats.  - 
1975 
http://www.ncbi.nlm.nih.gov/pubmed/1171470 
Only abstract available online.  
    "
Serotonin-depleting lesions of midbrain raphe (extensive lesions located within dorsal and partly median raphe muclei) induced intraspecific agressiveness in grouped Wistar male rats but failed to increase mouse-killing behaviour."  
 



Somatodendritic 5-HT1A Autoreceptors Mediate the Anti-Aggressive Actions of 5-HT1A Receptor Agonists in Rat (PubMed)  - 2000   
Full length HTML and PDF available online for free. 
    "
These data provide extensive evidence that the anti-aggressive effects of 5-HT1A receptor agonists are expressed via their action on somatodendritic 5-HT1A autoreceptors, thereby most likely attenuating intruder-activated serotonergic neurotransmission.
"


Absence of 5-HT(1B) receptors is associated with impaired impulse control ... knockout mice (PubMed) - 2001    
     "To nonentrained stimuli like disturbance stress and confrontation with an intruder, 5-HT(1B) KO mice showed exaggerated physiologic and behavioral responses. These mice displayed behavioral disinhibition, measured as increased social interest and aggression to an intruder mouse. However, in response to well-entrained stimuli like daily light transitions, responses were smaller in 5-HT(1B) KO than in wild type mice, suggesting that hyperreactivity is stimulus specific.




















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